Ex vivo and in vitro protective effects of kolaviron against oxygen-derived radical-induced DNA damage and oxidative stress have been found in human lymphocytes and rat liver cells. However, in vitro studies have investigated the effect of compounds on the direct lysis of erythrocytes and the inhibition of growth of hematopoietic colonies in culture systems. The advice from the ACCS was that the toxicity profile of 2-butoxyethanol is consistent with Schedule 6 criteria and that it was adequately captured by the current generic entry for ethylene glycol monoalkyl ethers and their acetates, and the specific 2-butoxyethanol and its acetates Schedule 6 entry. It is prepared by reacting 2-butoxyethanol with acetic acid, acetic acid anhydride, or acetic acid chloride. The delegate's decision was based on the fact that hexyloxyethanol's toxicity profile was different from the chemical class ethylene glycol monoalkyl ethers. 2-Butoxyethanol is a common ingredient in multi-purpose cleaners and window sprays. The ingested dose of butylglycol was about 25–30 g giving a blood level of 0.43 g/l upon admission. In a clinical setting, most commonly encountered glycol is ethylene glycol. This blog post is specific to disinfectants that are expected to be effective against the SARS-Cov-2 virus, the cause of COVID-19 in accordance with the … No increase in urine oxalate content was observed. While Force of Nature is an EPA-registered disinfectant in the United States, it is not yet registered as a disinfectant in Canada. The applicant's reasons for the proposal were: 2-Butoxyethanol is in Schedule 6, Appendix E and Appendix F of the Poisons Standard as follows: 2-BUTOXYETHANOL and its ACETATES except in preparations containing 10 per cent or less of such substances. It is thought that 2-butoxyethanol contributed to the significantly shorter lifespan of Exxon Valdez clean-up workers, which is why Corexit 9527, which also contains the chemical was banned in the United Kingdom. Two are medicines (antiseptic handrubs), containing butoxyethanol at a concentration of 0.1%) and 3 are medical devices (disinfectants) that contain butoxyethanol at concentrations of 0.25-9 % w/w. : AC403390000, AC403395000 CAS-No 111-76-2 Synonyms Butyl cellosolve; Ethylene glycol monobutyl ether, Butyl glycol Recommended Use Laboratory chemicals. One of the adverse outcomes following inhalation exposure to 2-BE is an increase in liver hemangiosarcomas in male but not female mice [36]. General Statements: A (For advice, contact a Poisons Information Centre (e.g. These compounds are mainly used as solvents and cleaning compounds. Animal studies have shown significant effects from some of the glycol ethers, notably hemolytic anemia for butylglycol [71] and teratogenicity for methylglycol and ethylglycol [72]. Based on limited data from case reports and one laboratory study, similar acute effects, including haemolytic and CNS effects are observed in humans and rats exposed to 2-butoxyethanol, although the effects are observed at much higher exposure concentrations in humans than in rats. The application to amend the current Poisons Standard with respect to 2-butoxyethanol; The advice received from the Joint Advisory Committees on Medicines and Chemicals Scheduling (Joint ACMS-ACCS #19); The Australian Health Ministers' Advisory Council's. It is estimated that 16.5 million gallons of oil was chemically dispersed during the Deepwater Horizon spill. There was an indication of ethanol inhibition of butylglycol metabolism and of an effect of hemodialysis in this patient. Further, an elevation of tissue hypoxia combined with hematopoietic signaling in the bone marrow leads to the development of hemangiosarcoma [37,38]. 2-butoxyethanol; ethyleneglycol monobutyl ether; butyl cellosolve CAD - Chemical Agents Directive, Art. The results of in vitro studies indicate that human red blood cells are not as sensitive as rat red blood cells to the haemolytic effects of 2-butoxyethanol and 2-butoxyacetic acid and also that red blood cells are more sensitive to haemolysis by 2-butoxyacetic acid than to haemolysis by 2-butoxyethanol. The committee considered that the acute toxicological profile, particularly in regard to eye and skin irritancy and the ready absorption by the dermal route, indicated that Schedule 6 remained appropriate for this compound and did not support the proposal for rescheduling. 2-BUTOXYETHANOL and its ACETATES except in preparations containing 1020 per cent or less of such substances. loss of coordination, sluggishness and narcosis). Linda A. Malley, in Encyclopedia of Toxicology (Second Edition), 2005. The delegate accepted the ACCS advice that the current scheduling of 2-butoxyethanol remained appropriate. Respiratory irritant consistent with Schedule 6 factors of the SPF. 2-Butoxyethanol was identified as a causal agent in the health problems experienced by cleanup workers after the 1989 Exxon Valdez oil spill. Until this is complete we can not claim that it is a disinfectant in Canada. The Novel Human Corona Virus that originated in Wuhan China now called SARS-CoV-2 the cause of COVID-19 has been declared a pandemic. Canada completed its assessment of 2-butoxyethanol in 2002 and as a result developed regulations to limit its concentration in a variety of consumer products intended for indoor use: 2-Butoxyethanol Regulations (SOR/2006-347). 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Many oxidants cause hemolysis by this mechanism (e.g., acetanilide, naphthalene, phenol; Table 22.2). In experimental studies, 2-butoxyethanol increased liver tumors in B6C3F1mice after chronic exposure. Fibrogenesis was not an absolute requirement for this promotion. 2-Butoxyethanol was identified as a causal agent in the health problems experienced by cleanup workers after the 1989 Exxon Valdez oil spill. 2-Butoxyethanol is readily absorbed via all routes of exposure (inhalation, dermal, ingestion) with low to moderate acute toxicity via oral, dermal and inhalation routes. 111-76-2. The delegate also decided to create new Appendices E, F and I entries specifically for hexyloxyethanol. phone Australia 13 11 26; New Zealand 0800 764 766) or a doctor (at once)), E2 (If in eyes, hold eyelids apart and flush the eye continuously with running water. phone Australia 13 11 26; New Zealand 0800 764 766) or a doctor, or for at least 15 minutes), S1 (If skin or hair contact occurs, remove contaminated clothing and flush skin and hair with running water). An assessment of its uses in cleaning products was completed in 1996. By continuing you agree to the use of cookies. The application proposes to amend the Schedule 6 entry for 2-butoxyethanol in the Poisons Standard to increase the exemption concentration from 10 per cent to 20 per cent. Butoxyethanol is not permitted for use in aerosol dispenser (sprays). Used in industry for degreasing and detergent applications.2-n-Butoxyethanol is used in the industry for degreasing and detergent applications. 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