4.3 Detection limit of the overall procedure (DLOP). 77-185. Figure 4.7.2. Dipropylene glycol is a mixture of three isomeric chemical compounds, 4-oxa-2,6-heptandiol, 2-(2-hydroxy-propoxy)-propan-1-ol, and 2-(2-hydroxy-1-methyl-ethoxy)-propan-1-ol. (Section 4.10.1), 2.5.3 Desorbed samples remain stable for at least 24 h. (Section 4.10.2), 2.6 Recommended air volume and sampling rate. There was no evidence of skin irritation from prolonged or repeated contact with the pure liquid. Synonym: 1,2-Propanediol monomethyl ether acetate, 1-Methoxy-2-propyl acetate, MPA, PGMEA, Propylene glycol methyl ether acetate Linear Formula: CH … Also, concentrations over 200 ppm (40% saturated atmosphere) are difficult to attain, which suggests these high concentrations would not likely be found in workplace air. f ODOR THRESHOLD = 35 ppm f Odor thresholds vary greatly. solubility and is ideally suited as a coupling agent in a wide range of solvent systems. Wrap each sample lengthwise with a Form OSHA-21 seal. Dipropylene Glycol Monomethyl Ether ** DO NOT USE ** Dipropylene Glycol Methyl Ether Propanol, (2-Methoxymethylethoxy)-Dipropylene Glycol Monomethyl Ether. (Section 4.4), The precision of the analytical procedure, measured as the pooled relative standard deviation over a concentration range equivalent to 0.5 to 2 times the target concentration, is 0.14%. 5.4. "NEG and NIOSH basis for an occupational health standard: Propylene Glycol Ethers and Their Acetates"; 1991, U.S. Department of Health and Human Services, Public Health Service, Center for Disease Control, NIOSH, Publication No. *Please select more than one item to compare. Position the sampler so it does not impede work performance or safety. NFPA SUPPLIER … 3.6.2 GC parameters (i.e. 3.2.6 GC grade nitrogen, air, and hydrogen. For example, inject 6.00 µL of DPGME into a vial containing 1.0 mL of desorption solvent. The direct measurement of YBR and SDBR in chromatographic methods is typically inconvenient and difficult because YBR is usually extremely low. 3.2.2 Methylene chloride, chromatographic grade. 5.9). It is a solvent used in paints, pastes, dyes, resins, brake fluids and inks, and in making cosmetics. 2.3.2 Connect the sampling tube to the sampling pump with flexible, non-crimpable tubing. It is desirable to utilize a sampling tube holder that shields the employee from the sharp, jagged end of the sampling tube. 2.3.8 List any compounds that could be considered potential interferences, especially solvents, that are being used in the sampling area. %PDF-1.6 %���� 0000003829 00000 n Values of 2267.4 and 101.4 were obtained for A and SEE respectively. The reported desorption efficiency ranged from 60.4% at 2.954 mg to 89.1% at 12.01 mg of DPGME. 0000009004 00000 n (Refs. After assuring that the RSDs satisfy the Cochran test for homogeneity at the 95% confidence level, the RSDP was calculated to be 0.14%. 0000001694 00000 n DIPROPYLENE GLYCOL METHYL ETHER may react violently with strong oxidizing agents. If samples fall outside of the concentration range of prepared standards, prepare and analyze additional standards to ascertain the linearity of response. Six samples were analyzed immediately after generation, fifteen were stored in a refrigerator at 0°C, and fifteen were stored in a closed drawer at ambient temperatures of 20-25°C. Fill out the form below and we will … Dipropylene glycol, on the other hand, is a byproduct of the manufacture of propylene glycol. Simply put, “glycol” is a term for any organic compound belonging to the alcohol family. 3.2.3 Methanol, chromatographic grade. Sampler capacity was determined by using a total hydrocarbon analyzer to monitor the effluent from sampling tubes containing only the 100-mg section of charcoal while sampling at 0.1 L/min from an atmosphere containing 202 ppm of DPGME. 0000004072 00000 n (Ref. Dipropylenglycolmonomethylether Dipropylene glycol monomethyl ether (mixture of isomeres) for synthesis. 2.6.3 When short-term samples are collected, the air concentration equivalent to the reliable quantitation limit becomes larger. The determination of the standard error of estimate (SEER) for a regression line plotted through the graphed storage data allows the inclusion of storage time as one of the factors affecting overall precision. Figure 3.5.3. 0000003105 00000 n Dipropylene Glycol Methyl Ether 34590-94-8,(1) Used in flexographic printing ink and oil based screen printing ink_OKCHEM The RQL is defined as the amount of analyte that gives a response (YRQL) such that. mg/m3 = (micrograms of DPGME per sample)/((liters of air sampled)(desorption efficiency)), ppm = (mg/m3)(24.46)/(molecular weight of analyte) = (mg/m3)(0.1650), where 24.46 is the molar volume at 25°C and 101.3 kPa (760 mmHg) 3.1.3 An electronic integrator or some other suitable means of measuring peak areas. 5.8. Mention of any company name or commercial product does not constitute endorsement by OSHA. trailer It is expected that severe exposure would produce similar effects in humans, but high concentrations are disagreeable and not tolerated. The equation of the line is Y = 203.9X - 124. High vapor concentrations or direct contact of the eyes with the liquid causes transient irritation. The samples were reanalyzed with fresh standards. Strukturformel Vereinfachte Strukturformeln von vier Konstitutionsisomeren 1 bis 4 ohne Stereochemie: Allgemeines Name Dipropylenglycolmethylether Andere Namen Methoxypropoxypropanol The CIR Expert Panel evaluated the scientific data and concluded that Butylene Glycol, Hexylene Glycol, Ethoxydiglycol and Dipropylene Glycol are safe for use in cosmetics and personal care products. This GPS Safety Summary is a high-level summary intended to provide the general public with an overview of product safety information on this chemical substance. At 2-4 day intervals, three samples were selected from each of the two storage sets and analyzed. This procedure is necessary for any method using charcoal collection and carbon disulfide desorption because the relative proportion of isomers in DPGME can vary by lot and manufacturer. 2.3.6 Submit at least one blank sampling tube with each sample set. Occupational Safety and Health Administration, Severe Storm and Flood Recovery Assistance. 2.1.2 Samples are collected with 7-cm × 4-mm i.d. Hathaway, G.J., et al., Ed., "Proctor and Hughes' Chemical Hazards of the Workplace", 3rd ed., Van Nostrand Reinhold, New York, 1991. This standard contains 5688 µg of DPGME per sample. The key difference between dipropylene glycol and propylene glycol is that dipropylene glycol is a mixture of three isomers, whereas propylene glycol is an organic compound having two alcohol groups.. Propylene glycol is very useful in the production of many polymer materials. (Section 4.6) This includes an additional 5% for sampling error. 2.3.7 Record sample volumes (in liters of air) for each sample. Plot of the data from Table 4.3 to determine the DLOP of 1.5 µg/sample (25 ppb, 150 µg/m3). 2.7.2 Suspected interferences should be reported to the laboratory with submitted samples. (Ref. But if the desorption efficiencies are not the same for each isomer, they must be quantitated separately with individual desorption efficiency corrections, and then the resulting amounts are summed to determine the total amount of DPGME. In the past, OSHA has determined airborne concentrations based on a method validated by NIOSH (Ref. 0000010968 00000 n It is a clear, colourless, viscous liquid which has a slight ether odour. After the original analysis was performed three vials were recapped with new septa while the remaining three retained their punctured septa. Dipropylene glycol methyl ether (DPGME) is one of the most commonly used propylene glycol ethers in industry and is discussed in a recently published NEG/NIOSH document. Product identifier Product form : Substance: CAS-No. 2.3.5 After sampling for the appropriate time, immediately remove the sampling tube and seal it with plastic caps. 3.8.1 Adhere to the rules set down in your Chemical Hygiene Plan. May generate flammable and/or toxic gases with alkali metals, nitrides, and other strong reducing agents. 0000003601 00000 n 5.11 "Hawley's Condensed Chemical Dictionary"; 12th ed. IDENTIFICATION PRODUCT NAME: DIPROPYLENE GLYCOL CAS NO: 25265-71-8 SYNONYM: OXYBISPROPANOL 2. Reanalysis of these samples after addition of 125 mg of magnesium sulfate brought the efficiencies nearly up to that from dry charcoal. Uses [ edit ] The back (50-mg) section is analyzed primarily to determine if there was any breakthrough from the front (100-mg) section during sampling. Di(propylene glycol) methyl ether is an organic solvent with a variety of industrial and commercial uses. For problems with accessibility in using figures and illustrations, please contact the Salt Lake Technical Center at 801-233-4900.These procedures were designed and tested for internal use by OSHA personnel. The DPGME concentration for samples is obtained from the appropriate calibration curve in terms of micrograms of analyte per sample, uncorrected for desorption efficiency. Also, a desorption efficiency less than 75% does not meet one of the evaluation requirements used by the Organic Methods Evaluation Branch of the OSHA Salt Lake Technical Center (SLTC). 0000018499 00000 n The desorption efficiencies are constant with concentration and are not affected by the presence of water, so a drying agent is not needed for the desorption step. Calibration curve constructed from the data in Table 4.5. 83; 2-Butoxyethanol and 2-Butoxyethyl Acetate", OSHA Salt Lake Technical Center, unpublished, Salt Lake City, UT 84165-0200, May 1990. 26 0 obj <> endobj "American Conference of Governmental Industrial Hygienists: Documentation of the Threshold Limit Values"; 5th ed., p. 221, Cincinnati, OH (1986). Samples are collected by drawing air through standard size (6-mm o.d., 100/50-mg sections) coconut shell charcoal tubes. 3.6.3 When necessary, the identity or purity of an analyte peak may be confirmed with additional analytical data. The front section contains 100 mg and the back section contains 50 mg of charcoal. Dipropylene Glycol Methyl Ether is the polypropylene glycol ether of methyl alcohol that conforms to the formula: C 7 H 16 O 3 where n has an average value of 2. Search term: "propylene glycol methyl ether" Compare Products: Select up to 4 products. The samples were submitted to an SLTC service branch for analysis. May initiate the polymerization of isocyanates and epoxides. Example of one determination of the 5% breakthrough volume. MATERIAL SAFETY DATA SHEET(MSDS)- DIPROPYLENE GLYCOL 1. This is the amount of analyte that will give a response that is significantly different from the background response of a reagent blank. All tubes should be from the same lot. This is the amount, when spiked on a sampler, that would produce a peak approximately 10 times the baseline noise for a sample blank. Search results for dipropylene glycol monomethil ether at Sigma-Aldrich PPG-2 Methyl Ether is a polypropylene glycol ether of methyl alcohol. 3.2.4 A suitable internal standard, reagent grade. 800-321-6742 (OSHA) Possible interferences should be reported to the laboratory with submitted samples by the industrial hygienist. : 34590-94-8 Product code : 00110 Chemical structure : … 0000007596 00000 n The RQL is considered the lower limit for precise quantitative measurements. The equation of the line is Y = 2267X - 162. View All 101 Related Papers .   and the molecular weight of DPGME = 148.2. For this evaluation, commercially prepared sampling tubes were purchased from SKC, Inc. (Fullerton, CA, Catalog No. (Sections 4.1 and 4.2), 1.2.2 Detection limit of the overall procedure, The detection limit of the overall procedure is 1.5 µg per sample (25 ppb or 150 µg/m3). (Section 4.10.1), 2.5.2 The desorption efficiency at 0.05, 0.1, and 0.2 times the target concentration was found to be 97.0%, 98.0%, and 98.2% respectively. Washington, DC 20210 The atmosphere was at approximately 80% relative humidity and 20-25°C. 0000000976 00000 n 14 matches found for propylene glycol methyl ether. Technical Names: (Methyl-2-Phenoxyethoxy)Propanol; 1-(1-Methyl-2-Propoxyethoxy)Propan-2-ol; 2-Propanol, 1-(1-Methyl-2-Propoxyethoxy)-Dipropylene Glycol Monopropyl Ether … 3 matches found for Dipropylene glycol methyl ether . 3.2.1 Dipropylene glycol methyl ether, reagent grade. 3.1.1 A GC equipped with a flame ionization detector. In cases where the desorption efficiency is not constant, calculations to determine analyte concentrations are complicated through the use of a desorption efficiency curve. 0000004294 00000 n No individual sample result deviated from its theoretical value by more than the precision reported in Section 1.2.5. 226-01, Lot 120). It is frequently used as a substitute for the more toxic DEGME (diethylene glycol methyl ether). May initiate the polymerization of isocyanates and epoxides. Also, 10 L is commonly recommended for solvent vapors collected on charcoal tubes. Dipropylene glycol. DOT ID & Guide . A graphical representation of one of the tests is shown in Figure 4.9. Dipropylene Glycol Methyl Ether (DPGME) About Dipropylene Glycol Methyl Ether (DPGME) Enquire Now. Aldrich Chemical Lot 11329LW 3-octanol was used in this evaluation. (2-METHOXYMETHYLETHOXY)- PROPANOL, (2-METHOXYMETHYLETHOXY)PROPANOL, 1-(2-METHOXYPROPOXY)- 2-PROPANOL, 1-(2-METHOXYPROPOXY)-2-PROPANOL, DIPROPYLENE GLYCOL MONOMETHYL ETHER, METHOXY DIPROPYLENE GLYCOL, POLYOXYPROPYLENE (2) METHYL ETHER, POLYPROPYLENE GLYCOL (2) ME THYL ETHER, PPG-2 METHYL ETHER… The recommended air volume is significantly lower than the breakthrough volume, but 10 L was chosen to provide a reasonable safety margin in the event other solvent vapors are present in the sampled air. Plot of the data from Table 4.2 to determine the DLAP of 0.13 ng. 1.1.2 Toxic effects (This section is for information only and should not be taken as the basis of OSHA policy. (Section 4.5). 2.1.1 Samples are collected using a personal sampling pump calibrated, with a sampling device attached, to within ±5% at the recommended flow rate. 0000001919 00000 n 2.6.2 For short-term samples collect 1.5 L at 0.1 L/min (15-min samples). Dipropylene glycol monomethyl ether. × 6-mm o.d. IDENTIFICATION OF THE SUBSTANCE AND OF THE COMPANY/UNDERTAKING Trade name : DIPROPYLENE GLYCOL CAS Number: : 25265- 71 -8 Chemical Name :1,1-Oxydi-2-Propanol Synonyms :Methyl-2(Methyl-2) Oxybispropanol, DPG, 2,2- Dihydroxyisopropyl Ether, 1,1-Oxydi-2-Propanol COMPANY IDENTIFICATION Supplier: Pon Pure … In general, the presence of other contaminant vapors in the air will reduce the capacity of charcoal to collect DPGME. A 30-m × 0.32-mm i.d. 3.2.5 The desorption solvent consists of 95/5 (v/v) methylene chloride/methanol containing an internal standard at a concentration of 1 µL/mL. And with its excellent stability, solvency, and coupling performance. 5.1. The use of 99/1 (v/v) carbon disulfide/N,N-dimethylformamide (CS2/DMF) was investigated as an alternative desorption solvent because it is used for the analysis of many solvent vapors collected on charcoal and analyzed at SLTC. Discard the glass tubes, urethane foam plugs and glass wool plugs. DOWANOL DPM glycol ether . Synonym: 1,2-Propanediol monomethyl ether acetate, 1-Methoxy-2-propyl acetate, MPA, PGMEA, Propylene glycol methyl ether acetate Linear Formula: CH … Sample concentrations must be bracketed by standards. DPGME at 300 ppm caused eye and nasal irritation to humans. 5.1 unless otherwise noted). 0 0000003566 00000 n 1 ppm = 6.06 … 3.8.3 Wear safety glasses and a lab coat at all times while in the lab area. fused silica, Stabilwax-DA®, 1-, = estimated response from regression curve, = estimated % recovery from the regression line at the same given time, Dipropylene Glycol Methyl Ether (Organic Method #101). (Section 4.9), 2.5.1 The average desorption efficiency for DPGME from Lot 120 charcoal over the range of 0.5 to 2 times the target concentration is 99.4%. MATERIAL SAFETY DATA SHEET (MSDS) www.lobachemie.com 07/12/2018 1/8 DIPROPYLENE GLYCOL MONOMETHYL ETHER (MIXTURE OF ISOMERSE) FOR SYNTHESIS MSDS CAS-No. Dipropylene glycol is a colorless, nearly odorless liquid with a high boiling point and lo… 0000000016 00000 n The DLAP was calculated to be 0.13 ng. column and column temperature) may be changed to possibly circumvent interferences. 5.7. The desorption efficiencies from dry charcoal ranged from 76-93% for the isomers at a loading of 6.0 mg of DPGME. Ten analytical standards were prepared in equal descending increments with the highest standard containing 12.0 µg/mL. PROPYLENE GLYCOL ETHYL ETHER may react violently with strong oxidizing agents. 5.9. The DLOP is measured as mass per sample and expressed as equivalent air concentrations, based on the recommended sampling parameters. 3.1.2 A GC column capable of separating the analyte of interest from the desorption solvent, internal standard and any interferences. It is produced during the manufacture of propylene glycol from propylene oxide along with tripropylene glycol and higher glycols. It finds use as a less volatile alternative to propylene glycol methyl ether and other glycol ethers. 124, Wed. June 30), 35344. 0000011930 00000 n Fisher Lot 913607 was used in this evaluation. 34590-94-8 RTECS No. CH₃OC₃H₆OC₃H₆OH. 0000002518 00000 n 0000018697 00000 n 200 Constitution Ave NW Storage samples were generated by sampling from test atmospheres containing DPGME at the target concentration. 2.6.1 For long-term samples collect 10 L of air at 0.1 L/min (100-min samples). (Ref. (Section 4.8). It is used as a solvent and as a coalescent for water-borne latex coatings. The Department of Labor does not endorse, takes no responsibility for, and exercises no control over the linked organization or its views, or contents, nor does it vouch for the accuracy or accessibility of the information contained on the destination server. The 95% confidence intervals are drawn about their respective regression lines in the storage graphs, as shown in Figures 4.7.1 and 4.7.2. Mass spectra for six of the isomers, which were separated using similar conditions given in Section 3.5, were obtained from a Perkin-Elmer Ion Trap Detector interfaced to a Hewlett-Packard Series II GC. %%EOF Dipropylene glycol monomethyl ether (also known as Methoxy Propoxy Propanol, Oxybispropanol, dipropylene glycol methyl ether, DPM, and Dowanol DPM) is a propylene oxide-based/P series glycol ether and has the formula C 7 H 16 O 3. It is determined from the regression line data obtained for the calculation of the DLOP (Section 4.3). 0000008483 00000 n 0000015529 00000 n These spiked samplers, plus a sample blank, were analyzed with the recommended analytical parameters, and the data obtained used to calculate the required parameters (A and SEE) for the calculation of the DLOP. 5.3) revealed that the desorption efficiency was not constant, the desorption efficiency of the individual isomers of DPGME was not investigated, and the desorption efficiency from wet charcoal was not addressed. 3.6.1 Any compound that produces a response on a flame ionization detector and has the same general retention time of any of the DPGME isomers or the internal standard is a potential interference. Dipropylene glycol dimethyl ether. [:en] Dipropylene Glycol N-propyl Ether Dipropylene Glycol n-Propyl Ether (DPnP) is a colorless liquid with an ether-like odor that evaporates slowly. 5.10. 59 0 obj <>stream "Documentation of the NIOSH Validation Tests"; U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, Division of Physical Sciences and Engineering; Cincinnati, OH, 1977, Backup Data Report No. The DLAP is measured as the mass of analyte actually introduced into the chromatographic column. Users must request such authorization from the sponsor of the linked Web site. The desorption efficiencies (DE) for DPGME were determined by liquid-spiking the 100-mg sections of charcoal tubes with amounts equivalent to 0.05 to 2 times the target concentration. For example, the reliable quantitation limit is 560 ppb (3390 µg/m3) when 1.5 L is collected. Figure 4.3. Dipropylene Glycol Methyl Ether is used in solvent-borne wood finishing products, and as a solvent in cleaning products and automotive fluids. 2.3.9 Ship any bulk sample(s) in a container separate from the air samples. The method specifies collection of the vapors on activated charcoal, desorption of the charcoal with carbon disulfide, and analysis by GC using flame ionization detection. The average 5% breakthrough volume from three determinations was 31.5 L (RSD=6.7%). Synonyms. 2.3.4 To avoid channeling, place the sampling tube vertically in the employee's breathing zone. startxref Belongs to the Following Reactive Group(s) Alcohols and Polyols; Ethers; Potentially Incompatible Absorbents. 5.4-5.5) For those analytes, the recovery from wet charcoal is significantly lower unless a drying agent such as magnesium sulfate is used in the desorption step. For this evaluation, a Hewlett-Packard 5890A Gas Chromatograph equipped with a 7673A Automatic Sampler was used. Aldrich Chemical Lot 08413CY was used in this evaluation. Chromatogram at the target concentration.Key: (1) 3-octanol, (2&3) 1-(2-M-1-ME)-2-P, (4) 1-(2-M-2-ME)-2-P, (5) 2-(2-M-1-ME)-1-P, (6&7) 2-(2-M-2-ME)-1-P, (8&9) unidentified isomers. If a dispenser is not available, a 1.0-mL volumetric pipet may be used. Dipropylene Glycol is used as a solvent, coupling agent and chemical intermediate. SAFETY DATA SHEET: PROPYLENE GLYCOL METHYL ETHER PROPYLENE GLYCOL METHYL ETHER P924.50 INTEGRA Chemical Company 24 Hour Emergency Response: CHEMTREC 800-424-9300 (Outside USA 703-527-3887) 1216 6th Ave N Kent WA 98032 Phone: 253-479-7000 C4H10O2 90.12 Recommended Use: Restrictions on Use: Commercial/industrial use Product Name: Formula and …